张龙龙
学历：博士
专家类别：副研究员，硕士研究生导师
邮箱：zhanglonglong@kmmu.edu.cn
通讯地址：澳门英皇娱乐昆明市呈贡区雨花街道春融西路1168号
邮编：650500
简历
工作经历：
(1) 2023-03至今,昆明医科大学,生物医学工程研究院,副研究员
博士后经历：
(1) 2021-01至2023-03,云南大学，省部共建云南生物资源保护与利用国家重点实验室
教育经历：
(1) 2017-09至2021-01,中国科学院昆明动物研究所,细胞生物学,博士
(2) 2014-09至2017-07,云南大学,遗传学,硕士
(3) 2010-09至2014-07,河南农业大学,生物技术,学士
研究方向
主要从事抗乳腺癌化合物的活性研究、作用机理解析和药效评价，以及通过开发新的乳腺癌治疗靶点筛选小分子化合物，发现小分子或药物的新机制和新的联合用药策略。
承担科研项目
1.线粒体靶向化合物Arthrocolins A-C抗肿瘤机制研究，国家自然科学基金，2023.01-2026.12，主持。
2.线粒体靶向化合物Arthrocolins A-C诱导卵巢癌细胞发生铁死亡的作用机制，澳门英皇娱乐博士后研究项目，2021.12-2023.01，主持。
研究成果（论文、专利、专著等）
发表论文（#表示共同第一作者；*表示通讯作者）
1. Zhuang Wu#, Qunfu Wu#, Wenli Yuan#, Yonghong Chen, Di Hu, Keqin Zhang, Deyao Deng*, Longlong Zhang*, Xuemei Niu*. Arthrocolins Synergizing with Fluconazole Inhibit Fluconazole-ResistantCandida albicans by Increasing Riboflavin Metabolism and Causing Mitochondrial Dysfunction and Autophagy. Microbiology Spectrum. 2023. 27: e0405122. (中科院1区，IF：9.04)
2. Qijun Zhou#, Xingyan Liu#, Longlong Zhang#, Rong Wang, Tingting Yin, Xiaolu Li, Guimei Li, Yuqi He, Zhaoli Ding, Pengcheng Ma, Shizhi Wang, Bingyu Mao*, Shihua Zhang*, Guodong Wang*. A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication, National Science Review, 2022. 9(11): nwac147. (中科院1区，IF-5年：23.92)
3. Xiaoyu Yang#, Yonghong Chen#, Longlong Zhang#, Jiangbo He#, Qunfu Wu, Shuhong Li, Jianghui Gou, Donglong Wang, Keqin Zhang, Shenghong Li*, Xuemei Niu*. Melanin Precursors Mediated Adaption to Temperature Changes in Fungus and Animal via Inhibition of Lipid-Mediated Ferroptosis, SCIENCE CHINA Life Sciences. 2023. (中科院1区，IF：10.384)
4. Longlong Zhang#, Yajun Liu #, Yonghong Chen, Zhuang Wu, Boran Liu, Qianyi Cheng, Keqin Zhang, Xuemei Niu*. Modulating activity evaluation of gut microbiota with versatile toluquinol. International Journal of Molecular Sciences. 2022. 23(18): 10700.
5. Longlong Zhang#, Maosen Ye#, Liang Zhu, Jingmei Cha, Chaocui Li, Yonggang Yao, Bingyu Mao*. Loss of ZC4H2 and RNF220 inhibits neural stem cell proliferation and promotes neuronal differentiation, Cells. 2020. 9(7): 1600.
6. Yonghong Chen#, Longlong Zhang#, Lijun Wang#, Xutong Yue, Qunfu Wu, Yang Jiang, Keqin Zhang, Xuemei Niu*. Acetylation of sesquiterpenyl epoxy-cyclohexenoids regulates fungal growth, stress resistance, endocytosis, and pathogenicity of nematode-trapping fungusArthrobotrys oligospora via metabolism and transcription. Journal of Agricultural and Food Chemistry. 2022. 70(20), 6145–6155. (中科院1区，IF-5年：6.04)
7. Xingwang Zhao#, Longlong Zhang#, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni*, Yi You*. Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis, Journal of Translational Medicine. 2021. 19(1): 64.
8. Qianqian Liu#, Longlong Zhang#, Yayan Zou, Ying Tao, Bing Wang, Bin Li, Ruai Liu, Boyong Wang, Lei Ding, Qinghua Cui, Jie Lin, Bingyu Mao, Wei Xiong*, Min Yu*. Modulating p-AMPK/mTOR pathway of mitochondrial dysfunction caused by MTERF1 abnormal expression in colorectal cancer cells. International Journal of Molecular Sciences. 2022. 23(20), 12354.
9. Ya Wen#, Qunfu Wu#, Longlong Zhang#, Jiangbo He#, Yonghong Chen, Xiaoyu Yang, Keqin Zhang, Xuemei Niu*, Shenghong Li*. Association of intrauterine microbes with endometrial factors in intrauterine adhesion formation and after medicine treatment.Pathogens. 2022. 11(7), 784.
10. Yonghong Chen#, Xiaoyu Yang#, Longlong Zhang#,Qunfu Wu#, Shuhong Li, Jianghui Gou, Jiangbo He, Keqin Zhang, Shenghong Li*,Xuemei Niu*. Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress. Heliyon. 2023. 9(2): e13066.
